A recent study suggests that people who come off popular GLP-1 drugs like Mounjaro or Wegovy may regain reduced body mass far faster than those who halt conventional lifestyle regimens.
Findings released in a leading health publication shows that while obese people often shed substantial amounts of their total mass while undergoing treatment, the weight returns at an estimated rate of nearly a kilo each month after stopping.
"People purchasing such treatments need to be informed of the risk of quick rebound weight gain when the therapy ends," warns expert Dr. Susan Jebb.
This pace of recovery suggests a return to pre-treatment weight within about a year and a half.
Comparing Therapies
The research, which reviewed dozens of trials involving thousands of participants, compared the results of the injectable medications with conventional dieting.
The team emphasize that people who lose weight through lifestyle changes alone typically experience a slower creep back—perhaps 100 grams monthly—once they finish.
The Reason for the Rapid Rebound
Nutrition scientists propose the way of the drugs accounts for the accelerated weight return.
The injections mimic a body's own chemical called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Long-term administration of GLP-1 levels far above than normal could lead to the body to produce less of its own natural hormone, and may also reduce sensitivity to its actions," said Dr. Adam Collins, a nutrition expert.
"Withdrawal of this medication means appetite is no longer kept in check, making binge eating far more likely."
A Chronic Issue?
Health authorities advise the injections for people with weight-linked health risks, alongside prescribed diet and exercise modifications.
Many experts say that, due to the significant potential of relapse, the treatment should be considered ongoing.
This perspective is reinforced by pharmaceutical companies, who note that the results "underscore the chronic nature of obesity," akin to managing conditions like hypertension.
User Experiences
Individuals who have stopped the medication report a sudden return of hunger.
"It was like something that goes on and I was suddenly extremely hungry," said a patient.
The struggle is exacerbated if patients have not established permanent dietary or behavioural changes during treatment.
Significant Interest
Figures suggest that a significant number of adults in the UK have tried these injections in the past year, with demand remaining high.
- Use is greater among women than men.
- The middle-aged demographic shows the greatest level of interest.
- Many access the medications through private healthcare rather than public health services.
Finally, researchers emphasize that while these medications are effective tools for weight loss, they are not a permanent fix and long-term success hinges on ongoing lifestyle changes.
